Challenges

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Rules Card Icon.png For corresponding page on Binding of Isaac: Rebirth Wiki, see Challenges.

Challenges are unique runs in the game. Challenges typically start the player off with one or more specific items which make normal play more difficult.

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MainPageModdedBosses.png Bosses MainPageChallenges.png Challenges MainPageModdedChapters.png Chapters MainPageModdedCharacters.png Characters Questionmarkisaac.png Curses/Blessings MainPageModdedItems.png Items Dataminer Icon.png Mods
Baby Transformation.png Modders/Teams MainPageModdedMonsters.png Monsters MainPageModdedObjects.png Objects MainPageModdedPickups.png Pickups MainPageModdedRooms.png Rooms MainPageModdedTransformations.png Transformations MainPageModdedTrinkets.png Trinkets