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Bosses

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Rules Card Icon.png For corresponding page on Binding of Isaac: Rebirth Wiki, see Bosses.

Bosses are strong monsters found in boss rooms at the end of a floor. The boss at the end of the floor must be defeated in order to advance to the next floor. The boss for a particular floor is chosen from the pool of bosses for the environment of the floor. Upon defeat, most bosses will drop an item from the boss item pool.

Bosses[edit | edit source]

Name Portrait Health Description ID.Variant.SubType Location Mod
The Peeping
The Peeping Portrait.png
550 Protected by some little buddies, the peeping uses a variety of blood barrages to attack isaac. 500.9900.0 The Womb The Peeping
Moira
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3000 +150 Fights using eyeballs. 777.0.0 N/A The Ritual
PeePeeDie
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2500 +200 An invulnerable boss with only one weak spot. 780.0.0 N/A The Ritual
Puck
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500 +30 Fights with magic runes that change how the player fights. 608.0.10 N/A Lunatic Mod
Souleater
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2000 Attacks the player using deadly blood lasers, and tricky projectile patterns. 800.125.0 N/A Godmode: Unleashed
Serpent
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? Shoots the player along some platforms. ?.?.? Septic Genesis+
Honeydrop
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110 A queen bee who attacks using shockwaves and by spawning flies to fight for him. 67.3.0 The Basement Devil's Harvest
Technopin
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100 An early boss that attacks by firing a laser towards isaac, and by leaping towards him. 62.0.10 The Cellar Devil's Harvest
Cacamancer
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300 A large boss that fights by summoning poopy friends. 699.0.0 The Caves Devil's Harvest
Mega Blister
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300 A large blister that summons not one, not three, but TWO little balls as part of their attack! 303.0.5 The Caves Devil's Harvest
Mega Portal
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200 +5 A big portal that summons other bosses to fight for them. 697.0.0 The Caves Devil's Harvest
Primordial Monstro
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250 This old Monstro protect himself with Ministros. 20.415.0 N/A Devil's Harvest
Mahalath
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477 A demonic boss that fights using their vomit. 777.0.0 The Depths Devil's Harvest

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MainPageModdedBosses.png Bosses MainPageChallenges.png Challenges MainPageModdedChapters.png Chapters MainPageModdedCharacters.png Characters Questionmarkisaac.png Curses/Blessings MainPageModdedItems.png Items MainPageModdedMonsters.png Monsters
MainPageModdedObjects.png Objects MainPageModdedPickups.png Pickups MainPageModdedPocketItems.png Pocket Items MainPageModdedRooms.png Rooms MainPageModdedTransformations.png Transformations MainPageModdedTrinkets.png Trinkets MainPageModdedUnlocks.png Unlockables
Dataminer Icon.png Mods Round Worm Trio Monster.png Teams